Author: Carmen Lim

Report date: 28 May 2020





Table 2.Broadly-defined mood disorder and anxiety disorders





Lifetime estimates



Mood and GAD [unadjusted]









Mood and GAD [adjusted]









Mood and Social Phobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -1.3780, p = 0.1682

Mood and Social Phobia [adjusted]









Mood and Specific Phobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -2.4802, p = 0.0131

Mood and Specific Phobia [adjusted]









Mood and Anxiety disorder [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.7708, p = 0.4408

Mood and Anxiety disorder [adjusted]









Period-prevalence estimates



Mood and GAD [unadjusted]









Mood and GAD [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.6759, p = 0.4991

Mood and Social Phobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -2.0829, p = 0.0373

Mood and Social Phobia [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.2974, p = 0.7662

Mood and Specific Phobia [unadjusted]









Mood and Specific Phobia [adjusted]









Mood and Anxiety disorder [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.3676, p = 0.7132

Mood and Anxiety disorder [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.0229, p = 0.9817





Table 3.Broadly-defined depressive disorder (DEP) and anxiety disorders





Lifetime estimates



DEP and Agoraphobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.0349, p = 0.9722

DEP and Agoraphobia [adjusted]









DEP and OCD [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.1056, p = 0.9159

DEP and OCD [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.7641, p = 0.4448

DEP and GAD [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.0362, p = 0.9711

DEP and GAD [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.9021, p = 0.3670

DEP and Panic disorder [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.8178, p = 0.0691

DEP and Panic disorder [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.5271, p = 0.1267

DEP and PTSD [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.5737, p = 0.1156

DEP and PTSD [adjusted]









DEP and Social phobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.5218, p = 0.1281

DEP and Social phobia [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.1172, p = 0.9067

DEP and Specific phobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.7060, p = 0.4802

DEP and Specific phobia [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -1.3571, p = 0.1748

DEP and Anxiety disorder [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.6070, p = 0.1080

DEP and Anxiety disorder [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.7119, p = 0.4765

Period-prevalence estimates



DEP and Agoraphobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.0628, p = 0.2879

DEP and Agoraphobia [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.0661, p = 0.9473

DEP and OCD [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.3151, p = 0.7527

DEP and OCD [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.9979, p = 0.3183

DEP and GAD [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.9574, p = 0.3383

DEP and GAD [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.2111, p = 0.8328

DEP and Panic disorder [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.5787, p = 0.5628

DEP and Panic disorder [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.3661, p = 0.7143

DEP and PTSD [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.0750, p = 0.9403

DEP and PTSD [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 3.5316, p = 0.0004

DEP and Social phobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.6595, p = 0.5096

DEP and Social phobia [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.8303, p = 0.0672

DEP and Specific phobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.3311, p = 0.1832

DEP and Specific phobia [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.9188, p = 0.0550

DEP and Anxiety disorder [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.9858, p = 0.3242

DEP and Anxiety disorder [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.3206, p = 0.1866

Table 4. Broadly-defined dysthymic disorder (DYS) and anxiety disorders





Lifetime estimates



DYS and Agoraphobia [unadjusted]









DYS and Agoraphobia [adjusted]









DYS and OCD [unadjusted]









DYS and OCD [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.4698, p = 0.6385

DYS and GAD [unadjusted]

## Warning in rma.uni(yi, vi, weights = weights, mods = X, intercept = FALSE, : Fisher scoring algorithm may have gotten stuck at a local maximum.
##   Setting tau^2 = 0. Check the profile likelihood plot with profile().

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.5431, p = 0.5870

DYS and GAD [adjusted]









DYS and Panic disorder [unadjusted]









DYS and Panic disorder [adjusted]









DYS and PTSD [unadjusted]









DYS and PTSD [adjusted]









DYS and Social phobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.1255, p = 0.2604

DYS and Social phobia [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.0830, p = 0.9338

DYS and Specific phobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 3.8401, p = 0.0001

DYS and Specific phobia [adjusted]









DYS and Anxiety disorder [unadjusted]









DYS and Anxiety disorder [adjusted]









Period-prevalence estimates



DYS and Agoraphobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.2088, p = 0.8346

DYS and Agoraphobia [adjusted]









DYS and OCD [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.3366, p = 0.7364

DYS and OCD [adjusted]









DYS and GAD [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.2972, p = 0.7663

DYS and GAD [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.3176, p = 0.7508

DYS and Panic disorder [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.3512, p = 0.1766

DYS and Panic disorder [adjusted]









DYS and PTSD [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.4479, p = 0.6542

DYS and PTSD [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 2.7177, p = 0.0066

DYS and Social phobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.4913, p = 0.6232

DYS and Social phobia [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.2015, p = 0.8403

DYS and Specific phobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.3604, p = 0.1737

DYS and Specific phobia [adjusted]









DYS and Anxiety disorder [unadjusted]









DYS and Anxiety disorder [adjusted]









Table 5. Broadly-defined bipolar disorder (BIPOLAR) and anxiety disorders





Lifetime estimates



Bipolar and Agoraphobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.1856, p = 0.8528

Bipolar and Agoraphobia [adjusted]









Bipolar and OCD [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.1284, p = 0.8979

Bipolar and OCD [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.2621, p = 0.7932

Bipolar and GAD [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.0878, p = 0.9301

Bipolar and GAD [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.6091, p = 0.1076

Bipolar and Panic disorder [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.3299, p = 0.7415

Bipolar and Panic disorder [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.6319, p = 0.5274

Bipolar and PTSD [unadjusted]









Bipolar and PTSD [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.3385, p = 0.7350

Bipolar and Social phobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.0766, p = 0.9390

Bipolar and Social phobia [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.2511, p = 0.8018

Bipolar and Specific phobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.7884, p = 0.4304

Bipolar and Specific phobia [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -1.1090, p = 0.2674

Bipolar and Anxiety disorder [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.8028, p = 0.4221

Bipolar and Anxiety disorder [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.5180, p = 0.6044

Period-prevalence estimates



Bipolar and Agoraphobia [unadjusted]









Bipolar and Agoraphobia [adjusted]









Bipolar and OCD [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.5635, p = 0.1179

Bipolar and OCD [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 1.0940, p = 0.2740

Bipolar and GAD [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -3.2318, p = 0.0012

Bipolar and GAD [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -1.4769, p = 0.1397

Bipolar and Panic disorder [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.6959, p = 0.4865

Bipolar and Panic disorder [adjusted]









Bipolar and PTSD [unadjusted]









Bipolar and PTSD [adjusted]









Bipolar and Social phobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.3799, p = 0.7040

Bipolar and Social phobia [adjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -0.4953, p = 0.6204

Bipolar and Specific phobia [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = 0.5462, p = 0.5849

Bipolar and Specific phobia [adjusted]









Bipolar and Anxiety disorder [unadjusted]

## 
## Regression Test for Funnel Plot Asymmetry
## 
## model:     mixed-effects meta-regression model
## predictor: standard error
## 
## test for funnel plot asymmetry: z = -1.3589, p = 0.1742

Bipolar and Anxiety disorder [unadjusted]